Enantioselective desymmetrization of meso-N-sulfonylaziridines with thiols

Desymmetrization of meso-N-sulfonylaziridines with thiols was realized using cinchonine-derived chiral quaternary ammonium salts as the catalyst. The corresponding chiral thio amines were provided in high yields (80–99%) and in good enantioselectivities (40–73% ee).

Figure optionsDownload as PowerPoint slide