کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1350699 | 980457 | 2006 | 8 صفحه PDF | دانلود رایگان |
The enzymatic resolution of racemic mixtures of hydroxy tellurides with a range of lipases has been investigated. Lipase-B from Candida antarctica (CALB) gave the best conversions, providing both enantiomers with high enantiomeric purity. A comparative study of the effect of solvent and substrate on the enzymatic kinetic resolution was performed.
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(S)-1-(Phenyltellanyl)-2-propanolC9H12OTeEe > 99%[α]D28=+5 (c 1.0, CH2Cl2)Absolute configuration: S
(S)-1-(n-Butyltellanyl)-2-propanolC7H16OTeEe > 99%[α]D23=+33 (c 1.0, CH2Cl2)Absolute configuration: S
(S)-1-(n-Butyltellanyl)-3-butanolC8H18OTeEe = 99%[α]D22=+7 (c 1.0, CH2Cl2)Absolute configuration: S
(R)-O-Acetyl-1-(phenyltellanyl)-2-propanolC11H14O2TeEe > 99%[α]D22=-6 (c 1.0, CH2Cl2)Absolute configuration: R
(R)-O-Acetyl-1-(n-butyltellanyl)-2-propanolC9H18O2TeEe = 98%[α]D22=+4 (c 1.0, CH2Cl2)Absolute configuration: R
(R)-O-Acetyl-1-(n-butyltellanyl)-3-butanolC10H20O2TeEe = 98%[α]D22=+18 (c 1.0, CH2Cl2)Absolute configuration: R
Journal: Tetrahedron: Asymmetry - Volume 17, Issue 15, 11 September 2006, Pages 2252–2259