Application of chiral ionic liquids in the copper catalyzed enantioselective 1,4-addition of diethylzinc to enones

Copper catalyzed enantioselective addition of diethylzinc to various enones has been achieved in the presence of a new class of chiral ionic liquid (ChirILs) derived from α-pinene. This first study on the application of ChirILs for the title reaction shows that the chiral reaction medium has a significant influence on chiral induction.

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3-EthylcyclohexanoneC8H14OEe = 76%[α]D = +119.7 (c 1, CHCL3)