Asymmetric conjugate addition of metal alkyl reagents catalyzed by copper complexes with BINPO: a hemilabile P,O-heterobidentate axially chiral ligand

We herein report the use of a new class of P,O-bidentate arylphosphine ligand for the asymmetric copper catalyzed conjugate addition of dialkylzinc and trialkylaluminium with the enantiomeric excesses reaching 91% while (R)-muscone was obtained with 77% ee.

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