کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1350880 980475 2005 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The aldol–annulation–fragmentation strategy toward the taxoid diterpene framework revisited. Instructive failures in the chemistry of medium ring containing systems
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
The aldol–annulation–fragmentation strategy toward the taxoid diterpene framework revisited. Instructive failures in the chemistry of medium ring containing systems
چکیده انگلیسی

Central intermediate 5 for the taxoid diterpene framework, prepared by the aldol–annulation sequence, permitted the construction of A-secotaxane frameworks incorporating differentiatable olefin and oxygen functionalities suitable for further elaboration. The key BC-subunits 9 and 8 have proven amenable to efficient conversion into both oxa-bridged 7 and its central eight-membered B-ring analogue 6, providing two potential precursors for taxoid construction. Although their further elaboration into 4 was not progressed at this stage, 6 and 7 are potentially useful synthetic intermediates. Extensive structural studies that included 800 MHz 1H (200 MHz 13C) NMR as well as X-ray crystallographic analyses of 7, 17, and 20 have contributed to the unambiguous elucidation of all the complex structures synthesized.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 16, Issue 19, 3 October 2005, Pages 3241–3255
نویسندگان
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