Chemical constituents from Lagopsis supina (Steph.) Ik.-Gal. ex Knorr

• Phytochemical investigation of the whole plants of Lagopsis supina led to the isolation of 18 compounds.
• Lagopsides A and B were identified as new phenylethanoid glycosides.
• Five compounds were isolated from the Labiatae family for the first time.
• Ten compounds were identified from the genus Lagopsis for the first time.
• The chemotaxonomic significance of the isolates was discussed.

Phytochemical investigation of the whole plants of Lagopsis supina (Steph.) Ik.-Gal. ex Knorr. led to the isolation of 18 compounds (1–18), including ten phenylethanoid glycosides (1–10), one phenylmethanoid glycoside (11), four megastigmane glycosides (12–15), and three monoterpenoid glycosides (16–18). Lagopsides A (1) and B (2) were identified as new phenylethanoid glycosides. This is the first report of compounds 7, 11, 12, 15, and 16 from the Labiatae family, while compounds 4–6, 8–10, 13–14, and 17–18 were isolated from the genus Lagopsis for the first time. The chemotaxonomic significance of these isolated compounds was summarized.