Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors

Members of a series of benzo[d]oxazol-2(3H)-one-quinolones were designed to serve as c-Met kinase inhibitors. The results of a SAR studies identified 13 as a highly potent inhibitor of this kinase.