کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1392226 | 1501127 | 2015 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of a platinum(II) complex with 2-(4-methoxy-phenyl) imidazo [4,5-f]-[1,10] phenanthrolin and study of its antitumor activity Synthesis of a platinum(II) complex with 2-(4-methoxy-phenyl) imidazo [4,5-f]-[1,10] phenanthrolin and study of its antitumor activity](/preview/png/1392226.png)
• One platinum(II) complex with phenanthrolin derivative was synthesized.
• The platinum(II) complex exhibited selective cytotoxicity toward tumor cells.
• Its antitumor activity was achieved via inhibiting telomerase activity.
• Its mechanism is interaction c-myc quadruplex and activation of caspase-3/9.
A new platinum(II) complex of [PtII(L) (pn)]Cl·2H2O (1) (pn = 1,3-propanediamine) with 2-(4-methoxy-phenyl)imidazo [4,5-f]-[1,10]phenanthrolin (H-L) was synthesized and characterized. In complex 1, the platinum adopts a four-coordinated square planar geometry. Complex 1 exhibited selective cytotoxicity against NCI–H460, BEL-7402, SK-OV-3, SK-OV-3/DDP and HeLa cell lines with IC50 values in the micromolar range (9.7–35.8 μM), but low cytotoxicity toward normal human liver HL-7702 cells. Complex 1 caused HeLa cell cycle arrest at S phase and it induced HeLa apoptosis by the activation of caspase-3/9. Various experiments showed that complex 1 preferred to bind with G-quadruplex in c-myc. Taken together, we found that complex 1 exerted its antitumor activity mainly via inhibiting telomerase by interaction with c-myc quadruplex and activation of caspase-3/9.
One platinum(II) complex with phenanthrolin derivative was synthesized. It exhibited selective cytotoxicity toward tumor cells achieved via inhibiting telomerase activity by interaction c-myc quadruplex and activation of caspase-3/9.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 89, 7 January 2015, Pages 77–87