کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1392351 | 1501131 | 2014 | 6 صفحه PDF | دانلود رایگان |
• Genistein was coupled with sugar derivatives.
• Genistein derivatives showed variable inhibition of NO and TNF-α production.
• 7-O-(6″-deoxy-α-d-galactopyrane-6″-yl)-genistein was not cytotoxic.
• 7-O-(6″-Deoxy-α-d-galactopyrane-6″-yl)-genistein appears as promising anti-inflammatory agent.
The isoflavone genistein 1 and some derivatives modulate IL-12, TNF-α and NO production by macrophages and lung cancer cell lines, and improve the clinical signs of experimental autoimmune encephalomyelitis (EAE). Seven genistein derivatives connected at C-6 position of a sugar, such as d-glucose and d-galactose, were synthesized. The ability to modulate macrophage response was evaluated, showing variable inhibition capacity of NO and TNF-α production in J774.A1 and RAW 264.7. Five of the seven compounds were non-cytotoxic; compound 8 was more effective to inhibit NO and TNF-α production, without affecting cell viability.
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Journal: European Journal of Medicinal Chemistry - Volume 85, 6 October 2014, Pages 615–620