Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis

• A series of 3-heteryl substituted pyrrolidine-2,5-dione were synthesized.
• They displayed promising inhibitory activity against Mycobacterium tuberculosis H37Rv.
• Some of them present inhibition activities against InhA.

In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against Mycobacterium tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA.

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