کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1392580 | 1501145 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• A series of 3-heteryl substituted pyrrolidine-2,5-dione were synthesized.
• They displayed promising inhibitory activity against Mycobacterium tuberculosis H37Rv.
• Some of them present inhibition activities against InhA.
In the present paper, we report the synthesis via catalytic Michael reaction and biological results of a series of 3-heteryl substituted pyrrolidine-2,5-dione derivatives as moderate inhibitors against Mycobacterium tuberculosis H37Rv growth. Some of them present also inhibition activities against InhA.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 71, 7 January 2014, Pages 46–52
Journal: European Journal of Medicinal Chemistry - Volume 71, 7 January 2014, Pages 46–52
نویسندگان
Tetiana Matviiuk, Giorgia Mori, Christian Lherbet, Frédéric Rodriguez, Maria Rosalia Pasca, Marian Gorichko, Brigitte Guidetti, Zoia Voitenko, Michel Baltas,