کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1392651 1501149 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo
چکیده انگلیسی


• A series of [1,2,4]triazolo[1,5-a]pyridinylpyridines were synthesized.
• All title compounds displayed inhibitory activity against HCT-116, U-87 MG and MCF-7 cell lines.
• The SAR of target compounds was preliminarily discussed.
• The compounds 1c and 2d with potent antiproliferative activities were tested for their effects on the AKT and p-AKT473.
• 1c exhibited potent anticancer effect in vivo.

A series of [1,2,4]triazolo[1,5-a]pyridinylpyridines were synthesized and characterized. Their antiproliferative activities in vitro were evaluated by MTT against three human cancer cell lines including HCT-116, U-87 MG and MCF-7 cell lines. The SAR of target compounds was preliminarily discussed. The compounds 1c and 2d with potent antiproliferative activities were tested for their effects on the AKT and p-AKT473. The anticancer effect of 1c was evaluated in mice bearing sarcoma S-180 model. The results suggest that the title compounds are potent anticancer agents.

A series of [1,2,4]triazolo[1,5-a]pyridinylpyridines were synthesized and their anticancer effects were evaluated in vitro and in vivo.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 67, September 2013, Pages 243–251
نویسندگان
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