کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1392739 1501150 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities
چکیده انگلیسی


• 4-(Dimethylaminomethylene)-1-phenyl-3-(pyridin-3-yl)-1H-pyrazol-5(4H)-one (enaminone) was reported.
• The chemical behavior of enaminone with some active methylene reagent was examined.
• The reactions were carried out by conventional heating and microwave irradiation.
• Most of the synthesized compounds were screened for antioxidant, antitumor and antimicrobial activities.

The chemical behavior of 4-(dimethylaminomethylene)-1-phenyl-3-(pyridin-3-yl)-1H-pyrazol-5(4H)-one (enaminone) (2) toward some active methylene reagents has been reported to give pyrazolopyridine derivatives. All the reactions were carried out by conventional heating and microwave irradiation technique. The antioxidant activity of the prepared compounds was studied using 1,1-phenyl-2-picrylhydrazyl (DPPH) assay. Compounds (4c) and (4d) showed the highest activity. The antitumor activity against liver and breast cell lines was tested. Compounds (6), (9) and (11) showed the highest activity for liver cell line while compounds (6) and (9) showed the highest activity for breast cell line. Compounds (4a–d) were screened for their antibacterial activity against Gram-positive, Gram-negative bacteria and antifungal activity.

New pyrazolopyridine compounds were prepared by conventional heating and microwave irradiation technique. The synthesized compounds were screened for antioxidant, antitumor and antimicrobial activities.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 66, August 2013, Pages 415–422
نویسندگان
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