کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1392792 | 1501161 | 2012 | 9 صفحه PDF | دانلود رایگان |

Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.
Some novel thienopyrimidine and fused thienopyrimidine derivatives with promising anti-inflammatory activity.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis and anti-inflammatory activity of novel thienopyrimidines.
► Some compounds exhibited good anti-inflammatory activity relative to diclofenac Na.
► Compounds 4, 9, 10 and 13 were found to have the highest anti-inflammatory activity.
Journal: European Journal of Medicinal Chemistry - Volume 55, September 2012, Pages 85–93