کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1392792 1501161 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents
چکیده انگلیسی

Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.

Some novel thienopyrimidine and fused thienopyrimidine derivatives with promising anti-inflammatory activity.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis and anti-inflammatory activity of novel thienopyrimidines.
► Some compounds exhibited good anti-inflammatory activity relative to diclofenac Na.
► Compounds 4, 9, 10 and 13 were found to have the highest anti-inflammatory activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 55, September 2012, Pages 85–93
نویسندگان
, , ,