Synthesis and antiproliferative evaluation of some new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine

► Novel amidino substituted bis-benzothiazolyl-pyridines and pyrazine were synthesized. ► Their antiproliferative activity against several human cancer cell lines was determinated. ► Diimidazolinyl-derivatives, exerted stronger concentration-dependent antiproliferative effects. ► Biological studies on SW620 cell line and BJ fibroblasts revealed oxidative stress as a possible mechanism.