Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety

A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug.

A novel series of pyrazolines were synthesized under MW and evaluated for varies biological activities. Few compounds displayed excellent pharmacological property.Figure optionsDownload as PowerPoint slideHighlights
► Microwave mediated synthesis of novel pyrazolines was achieved.
► Formation of pyrazoline was confirmed based on XRD studies.
► Results of antioxidant studies are highly encouraging.
► Few compounds displayed excellent anti-inflammatory and analgesic activity.