Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives

► New anti-TB compounds containing isocyanurate fragment have been synthesized. ► These compounds are potential inhibitors of β-ketoacyl synthase in mycobacteria. ► They have good activity against M. Tuberculosis (MIC 0.05-25 μg/mL). ► These compounds are nontoxic and highly species-specific. ► The efficacy varies with alkyl spacer length and combination of functional groups.