کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393019 | 1501175 | 2011 | 9 صفحه PDF | دانلود رایگان |
This work presents the interaction of two anthraquinones including quinizarin (1, 4-dihydroxyanthraquinone) and danthron (1, 8-dihydroxyanthraquinone) with CT-DNA in a mixture of Brittone–Robinson buffer (pH = 7) with 50% of ethanol by UV–vis absorption, circular dichroism spectroscopic methods and viscosity measurements. The PCA and INDICES methods were used for predicting the number of light-absorbing components. Partially intercalative and hydrogen binding were found to be the dominant binding modes between anthraquinones and CT-DNA. The effect of ionic strength and pH on the behavior of the above system and also the interaction of anthraquinones with ds and ss-DNA were used to confirm the mentioned binding modes. The EQUISPEC software and nonlinear least-squares analysis were applied for binding constant determination.
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► Interaction of quinizarin and danthron with CT-DNA by chemometric methods was studied.
► The PCA and INDICES methods are used for predicting the number of components.
► Partially intercalative and H-binding are the dominant binding modes.
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 7, July 2011, Pages 2630–2638