New condensed pyrroles of potential biological interest: Syntheses and structure–activity relationship studies

The Pyrrole derivatives Ia–d were prepared and utilized for the preparation of pyrrolo[2,3-d]pyrimidine derivatives IIa–c, III, IVa–e, V and VIIIa–c; pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine VI and pyrrolo[4,3e][1,2,4]triazolo[1,5-c]pyrimidine derivative derivatives VIIa–c. These some newly synthesized compounds were examined for their in vitro antimicrobial activity and in vivo anti-inflammatory. Result indicated that these compounds showed promising anti-inflammatory activity in comparison to ibuprofen (the standard anti-inflammatory drug). The structure–activity relationships (SAR) and anti-inflammatory activities of these compounds are also discussed in this paper.

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► We prepared some novel pyrrole and pyrrolopyrimidine derivatives.
► We evaluated them for anti-inflammatory and antimicrobial activities.
► Structure–activity relationship of the active compounds were described.
► Results demonstrated that the synthesized compounds are promising anti-inflammatory agents.