کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1393086 1501182 2010 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2-Azetidinone – A new profile of various pharmacological activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
2-Azetidinone – A new profile of various pharmacological activities
چکیده انگلیسی

2-Azetidinone, a β-lactam four member heterocyclic compound involved in research aimed to evaluate new products that possess interesting biological activities. These compounds reported for their antimicrobial and antifungal activities. Successful introduction of aztreonam as a potent inhibitor of cephalosporinase and ezetimibe as a cholesterol absorption inhibitor proved potential of 2-azetidinone moiety. Subsequently 2-azetidinones were highlighted as a potent mechanism based inhibitor of several enzymes like human tryptase, chymase, thrombin, leukocyte elastase, human cytomegalovirus protease and serine protease enzyme. These derivatives also known to possess antitubercular, anti-inflammatory, antitumor, anti-HIV, antiparkinsonian, antidiabetic and vasopressin V1a antagonist activity. The present review article focuses on the pharmacological profile of 2-azetidinones with their potential activities.

2-Azetidinone and their derivatives occupy a central place in medicinal chemistry due to their diverse and broad pharmacological profile. This article focuses on the various pharmacological profile of 2-azetidinone scaffold and development of novel derivatives with their potential activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 12, December 2010, Pages 5541–5560
نویسندگان
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