Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase

Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes.

Convenient synthesis of a series of novel (6-deoxygly-copyranosid-6-yl) sulfone derivatives and their bioevaluation against Ca2+-ATPase is reported. Yields were excellent in every case.Figure optionsDownload as PowerPoint slideResearch highlights
► Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes.
► Novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives have been synthesized.
► A high yielding general synthetic strategy has been used.
► The synthetic compounds were evaluated against Ca2+-ATPase.
► Compounds showed stimulatory effects on Mg2+ independent Ca2+-ATPase.