Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in μM. The compounds were non-cytotoxic and exhibited an important activity (12.6 μM). The appreciable activity of these compounds can be considered an important finding for the rational design of new leads for anti-TB compounds.

Several new mefloquine-oxazolidine derivatives have been synthesized and evaluated as antituberculosis agents. The compounds displayed substantial activities and high cell viability.Figure optionsDownload as PowerPoint slide