کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393175 | 1501193 | 2010 | 8 صفحه PDF | دانلود رایگان |

A simple approach to 1,1′,2,2′,3,3′,4,4′-octahydro-1,1′-biisoquinolines is described. Reaction of phenethylamines with oxalyl chloride led to N,N′-bis(phenethyl) oxamides (1). Cyclization of oxamides by using Bischler – Napieralski conditions gave 3,3′,4,4′-tetrahydro-1,1′-biisoquinoline(3) and unusual products 2, 4, 5. Reduction of 3,3′,4,4′-tetrahydro-1,1′-biisoquinolines with sodium boron hydride gave both rac-1,1′,2,2′,3,3′,4,4′-octahydro-1,1′-biisoquinolines(6) and meso-1,1′,2,2′,3,3′,4,4′ -octahydro-1,1′-biisoquinolines(7). Compound 6 was resolved to (1S, 1S′) (8) and (1R, 1R′) (9) furtherly. By treating all the biisoquinolines with K2PtCl4 afforded their cis-dichloridoplatinum (II) complexes (12–18). The antitumor activity of these complexes was evaluated.
A simple approach to 1,1’,2,2’,3,3’,4,4’-octahydro-1,1’- biisoquinolines is described. Treatment all the biisoquinolines with K2PtCl4 afforded their cis-dichloridoplatinum (II) complexes . The antitumor activity of these complexes was evaluated.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 1, January 2010, Pages 55–62