کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1393175 1501193 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antitumor activity of cis-dichloridoplatinum(II) complexes of 1,1′-biisoquinolines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antitumor activity of cis-dichloridoplatinum(II) complexes of 1,1′-biisoquinolines
چکیده انگلیسی

A simple approach to 1,1′,2,2′,3,3′,4,4′-octahydro-1,1′-biisoquinolines is described. Reaction of phenethylamines with oxalyl chloride led to N,N′-bis(phenethyl) oxamides (1). Cyclization of oxamides by using Bischler – Napieralski conditions gave 3,3′,4,4′-tetrahydro-1,1′-biisoquinoline(3) and unusual products 2, 4, 5. Reduction of 3,3′,4,4′-tetrahydro-1,1′-biisoquinolines with sodium boron hydride gave both rac-1,1′,2,2′,3,3′,4,4′-octahydro-1,1′-biisoquinolines(6) and meso-1,1′,2,2′,3,3′,4,4′ -octahydro-1,1′-biisoquinolines(7). Compound 6 was resolved to (1S, 1S′) (8) and (1R, 1R′) (9) furtherly. By treating all the biisoquinolines with K2PtCl4 afforded their cis-dichloridoplatinum (II) complexes (12–18). The antitumor activity of these complexes was evaluated.

A simple approach to 1,1’,2,2’,3,3’,4,4’-octahydro-1,1’- biisoquinolines is described. Treatment all the biisoquinolines with K2PtCl4 afforded their cis-dichloridoplatinum (II) complexes . The antitumor activity of these complexes was evaluated.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 1, January 2010, Pages 55–62
نویسندگان
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