کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1393195 1501193 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives
چکیده انگلیسی

A series of novel ferrocenyl pyrazolo[1,5–a]pyrazin-4(5H)-one derivatives was synthesized and characterized by 1H NMR, 13C NMR, IR, HRMS and X-ray diffraction analysis. Preliminary evaluation of biological applications showed that the compounds 6c and 6f inhibit the growth of A549 cells in dosage-dependent manners through cell cycle arrest.

Novel ferrocenyl pyrazolo[1,5–a]pyrazin-4(5H)-one derivatives were synthesized and characterized by spectroscopy and X-ray diffraction analysis. The compounds 6c and 6f were found to inhibit the growth of A549 cells through cell cycle arrest.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 1, January 2010, Pages 210–218
نویسندگان
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