کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1393278 | 1501195 | 2009 | 5 صفحه PDF | دانلود رایگان |
A series of d-glucopyranosyl-1,2,4-triazole-3-thione derivatives 1a–1d were synthesized by the reaction of 1,2,4-triazole-3-thione Schiff bases 5a–5d with 2,3,4,6-tetra-O-acetyl-σ-d-glucopyranosyl bromide. We demonstrate the conversion of 2 to 5, without the necessity of purification of both oxadiazole and triazole intermediates to afford the compounds 5. Their structures were confirmed by standard studies of 1H NMR, IR, MS and elemental analysis. Analogues 5 and 1 have shown cytotoxic activity against human MCF-7 and Bel-7402 malignant cell lines.
A series of 1,2,4-triazole-3-thione Schiff bases (5a–5d) and d-glucopyranosyl-1,2,4-triazole-3-thione derivatives (1a–1d) were synthesized, which have shown cytotoxic activity against human MCF-7 and Bel-7402 malignant cell lines.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 11, November 2009, Pages 4716–4720