Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarcosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles.The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration.

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