کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393337 | 1501203 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chiral tetrahydropyrans were designed and synthesized by allylations of enantiomerically enriched β-hydroxy ketones followed by iodocyclisations and nucleophilic replacement of iodo group with C2H5S− and SCN−. In vitro COX-1/-2 inhibitory activities and the docking studies of these compounds identify some of them as moderate inhibitors of COX-1 and COX-2 enzymes.
Enantioselective β-hydroxy ketones, obtained by the reactions of substituted benzaldehydes and acetone in presence of l-proline, on allylations followed by iodocyclisations and nucleophilic replacement reactions provided highly substituted tetrahydropyrans which act as moderate inhibitors of COX-1 and COX-2.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 3, March 2009, Pages 1278–1287
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 3, March 2009, Pages 1278–1287
نویسندگان
Palwinder Singh, Atul Bhardwaj, Satwinderjeet Kaur, Subodh Kumar,