کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393348 | 1501203 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A small library of 2-indolinone derivatives with the 2,6-dichlorophenyl ring at the N1 position and with varying substitutions including aryl groups at the 3-position were synthesized, and their structures were confirmed by spectral analysis. All molecules were screened for their in vitro cytotoxic activity on SW620 colon cancer cell lines. Among the designed series compounds 4c, 4f and 4j were found to be active at concentrations of 2–15 μg/ml. Some 3D-QSAR models were also built to understand the structure–activity relationship.
Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 3, March 2009, Pages 1355–1362
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 3, March 2009, Pages 1355–1362
نویسندگان
Vijay Virsodia, Atul Manvar, Kuldip Upadhyay, Rajesh Loriya, Denish Karia, Manu Jaggi, Anu Singh, Rama Mukherjee, Mushtaque S. Shaikh, Evans C. Coutinho, Anamik Shah,