کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393361 | 1501208 | 2008 | 11 صفحه PDF | دانلود رایگان |

A variety of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid were synthesized and screened for their analgesic and anti-inflammatory activities. The compounds were found to have longer activity profile exceeding that of indomethacin in carrageenan-induced rat paw edema model. Few selected compounds were also screened for their antipyretic, anti-arthritic and ulcerogenecity potential. From these studies it can be concluded that these compounds though have significant antipyretic activity did not act through the inhibition of TNF-α. The test compounds failed to prevent the development of secondary inflammation in adjuvant-induced arthritis assay. However, these compounds showed no ulcer formation at the tested dose level of 100 mg/kg p.o.
A series of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid amides were synthesized and screened for their anti-inflammatory and related biological activities. The synthesized compounds showed long duration of anti-inflammatory activity and were free from ulcerogenecity liability of common NSAIDs.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 10, October 2008, Pages 2092–2102