کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1393412 1501209 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines
چکیده انگلیسی

The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.

Various vicinal diaryl heterocycles (1) are found to be pharmacologically important in medicinal chemistry. In this paper 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines (17a–r) were synthesized and evaluated for antileukemic and antiplatelet activities. The 2,3-diaryl-1,4-diazepine motif showed an interesting antiplatelet activity profile.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 9, September 2008, Pages 2004–2010
نویسندگان
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