کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393441 | 1501211 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor](/preview/png/1393441.png)
چکیده انگلیسی
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1–2, 16–18, 23, and 25–26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
A series of amide and urea derivatives of benzothiazole have been synthesized and initially evaluated for their antiproliferative profile in a panel of cancer cell lines. Further potent compounds were investigated for their ability to inhibit Raf-1 activity.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 7, July 2008, Pages 1519–1524
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 7, July 2008, Pages 1519–1524
نویسندگان
Eun Young Song, Navneet Kaur, Mi-Young Park, Yinglan Jin, Kyeong Lee, Guncheol Kim, Ki Youn Lee, Jee Sun Yang, Jae Hong Shin, Ky-Youb Nam, Kyoung Tai No, Gyoonhee Han,