Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1–2, 16–18, 23, and 25–26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

A series of amide and urea derivatives of benzothiazole have been synthesized and initially evaluated for their antiproliferative profile in a panel of cancer cell lines. Further potent compounds were investigated for their ability to inhibit Raf-1 activity.Figure optionsDownload as PowerPoint slide