کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1393489 1501214 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives
چکیده انگلیسی

In the course of structure–activity relationship studies, diversely substituted 1-(β- d-acetylatedglucopyranosyl)isoindigo derivatives were prepared from indolines. New 7′-azaisoindigo analogues were also synthesized by coupling a glycosylated isatine and a 7-azaindolin-2-one derivative. Compounds containing a 7′-azaisoindigo framework have never been described before. To get an insight into the substitution pattern required for the best biological potencies, their antiproliferative activities were evaluated toward a human buccal carcinoma cell line (KB) and two human myeloid leukaemia cell lines (K562, HL60).

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 4, April 2008, Pages 755–762
نویسندگان
, , ,