کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393554 | 1501237 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Air to brain, blood to brain and plasma to brain distribution of volatile organic compounds: linear free energy analyses Air to brain, blood to brain and plasma to brain distribution of volatile organic compounds: linear free energy analyses](/preview/png/1393554.png)
Partition coefficients, Kbrain, for volatile organic compounds, VOCs, from air to brain have been collected for 81 compounds (air to human brain and air to rat brain). For the 81 VOCs a linear free energy equation (LFER) correlates log Kbrain with R2 = 0.923 and S.D. = 0.346 log units. Use of training and test sets gives a predictive assessment of 0.35–0.40 log units. Combination of log Kbrain with our previously listed values of log Kblood enables blood to brain partition, as log Pb-brain, to be obtained for 78 VOCs. These values can be correlated with R2 = 0.725 and S.D. = 0.203 log units; use of training and test sets allows a predictive assessment for log Pb-brain of 0.16–0.20 log units. Values for air to plasma were available for 21 VOCs. When these data were combined with the data on air to blood and air to brain, values for partition between (blood or plasma) to brain, Pbp-brain, were available for 99 VOCs. A LFER correlates this data with R2 = 0.703 and S.D. = 0.197 log units; use of training and test sets allows a predictive assessment for log Pbp-brain of 0.15–0.20 log units.
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 4, April 2006, Pages 494–502