کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393556 | 1501237 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH4Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels.
Novel dihydropyrimidin-(2H)-ones were obtained by ultrasound irradiation. Some of the synthesized compounds showed antioxidant activity.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 4, April 2006, Pages 513–518
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 4, April 2006, Pages 513–518
نویسندگان
Hélio A. Stefani, Carlindo B. Oliveira, Roberta B. Almeida, Claudio M.P. Pereira, Rodolpho C. Braga, Rodrigo Cella, Vanessa C. Borges, Lucielli Savegnago, Cristina W. Nogueira,