Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents

A series of 1,2,3-triazole and chalcone allied organosilatranes (7a-g, 8a-g, 9a-g) are synthesized and well characterized by various spectroscopic techniques. The synthesized compounds are passed through the computer based screening for their physicochemical properties and then tested for their antigiardial and antitrichomonal activities. The compounds showing good activities are then tested for their cytotoxicity against Hek-293 and HeLa cells.231