1,3,4-Thiadiazoles: A potent multi targeted pharmacological scaffold

• Thiadiazoles are attractive pharmacological targets.
• The present review provides an overview about the synthesis and biological properties of thiadiazoles.
• The present review is helpful for the researchers planning to work on thiadiazoles.

Despite a significant work on thiadiazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent biological activities. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects. This review throws light on the detailed synthetic approaches which have been used for the synthesis of thiadiazoles. This has been followed by the in depth analysis of the thiadiazoles with respect to their medicinal significance.

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