کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394027 1501124 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis, and antiviral activity of novel rutin derivatives containing 1, 4-pentadien-3-one moiety
ترجمه فارسی عنوان
طراحی، سنتز و فعالیت ضد ویروسی مشتقات راتین جدید حاوی 1، 4-پنتیدون 3-یک بخش
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Novel rutin analogs were synthesized.
• The synthesized compounds showed good antiviral activities.
• The EC50 value of 7r was 394.78 μg/mL against cucumber mosaic virus.
• Preliminary SAR was analyzed.

Rutin (compound 5) and some compounds (compounds 1–4 and 6) were isolated from Artemisia princeps Pamp (A. princeps Pamp.) and a series of novel rutin derivatives containing 1,4-pentadien-3-one moiety were designed and synthesized. The target compounds were characterized by proton nuclear magnetic resonance spectroscopy (1H NMR), carbon nuclear magnetic resonance spectroscopy (13C NMR), and ESI-MS. Bioassay results indicated that some of the compounds showed good to excellent antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) at 500 μg/mL in vivo. The 50% effective concentrations (EC50) of the compound 7r against CMV was 394.78 μg/mL, which was better than that of Ningnanmycin (432.22 μg/mL). These results indicated that novel rutin derivatives containing 1,4-pentadien-3-one moiety can effectively control CMV.

Novel rutin derivatives containing a 1,4-pentadien-3-one moiety were synthesized and evaluated for their antiviral activities. Compounds showed good activities against tobacco mosaic virus and cucumber mosaic virus.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 92, 6 March 2015, Pages 732–737
نویسندگان
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