کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394095 1501136 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity
چکیده انگلیسی


• We have synthesized fifteen new N-acyl-1-amino-2-alcohols, related to Aegeline.
• All were screened for lipid lowering, LDL-oxidation and antioxidant activity.
• Compounds 3, 11, 13 showed drug like lipid lowering, LDL-oxidation and antioxidant activity.

As a part of our drug discovery program, we identified an alkaloidal amide i.e. Aegeline (V) isolated from the leaves of Aegle marmelos as a dual acting agent (antihyperlipidemic and antihyperglycemic). In continuation of this program, we synthesized new N-acyl-1-amino-2-alcohols (N-acrylated-1-amino-2-phenylethanol and N-acylated-1-amino-3-aryloxypropanols) via Ritter reaction and screened for their in-vivo antihyperlipdemic activity in Triton induced hyperlipidemia model, LDL-oxidation and antioxidant activity. Compounds 3, 11 and 13 showed good antihyperlipidemic activity, LDL-oxidation as well as antioxidant activity and comparable activity with marketed antidyslipidemic drug.

New N-acyl-1-amino-2-alcohols (3 and 8–21) were synthesized and evaluated their antihyperlipdemic, LDL-oxidation and antioxidant activity. Compounds 3, 11 and 13 showed comparable activity with marketed antidyslipidemic drug.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 80, 10 June 2014, Pages 135–144
نویسندگان
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