کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394235 1501140 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPARγ
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPARγ
چکیده انگلیسی


• Novel urea derivatives as dual-acting agonists of GK and PPARγ were synthesized.
• Several agonists exhibited high enzyme activity and moderate hypoglycemic efficacy.
• The discovery may provide an effective approaching for treating T2DM.

Motivated by the discovery of a potential ligand that activates both glucokinase (GK) and perioxisome proliferator-activated receptor-γ (PPARγ), this work presents the rational design and synthesis of a series of novel urea derivatives as potent dual-target ligands of GK and PPARγ. The derivatives obtained, particularly compounds 14j, 14m, 15g, 15j, and 15s, showed relatively high enzyme activity and moderate blood glucose-lowering efficacy in normal ICR mice (GK activation fold >1.7, PPARγ activation percentage >38.8%, relative to rosiglitazone). The discovery of a dual-acting agent may provide an effective approach for treating type 2 diabetes mellitus.

A novel series of urea derivatives as potent dual-acting agonists of GK and PPARγ were designed and synthesized. The binding model was predicted by molecular docking simulation.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 76, 9 April 2014, Pages 182–192
نویسندگان
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