Evaluation of novel trans-sulfonamide platinum complexes against tumor cell lines

• The cytotoxicity profiles and cell cycle analyses is studied.
• trans-platinum complexes containing sulfonamides ligands are presented.
• trans-sulfonamide platinum complexes are able to overcome CDDP resistance.

Platinum-based drugs, mainly cisplatin, are employed for the treatment of solid malignancies. However, cisplatin treatment often results in the development of chemoresistance, leading to therapeutic failure. Here, the antitumor activity of different trans-sulfonamide platinum complexes in a panel of human cell lines is presented. The cytotoxicity profiles and cell cycle analyses of these platinum sulfonamide complexes were different from those of cisplatin. These studies showed that complex 2b with cyclohexyldiamine and dansyl moieties had the best antitumoral activities.

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