کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1394288 | 1501154 | 2013 | 11 صفحه PDF | دانلود رایگان |

A series of novel hybrid compounds between 2-benzylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 4-methoxyphenacyl group were vital for modulating cytotoxic activity. In particular, hybrid compounds 46 and 47 were found to be the most potent derivatives against 5 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721), respectively.
Figure optionsDownload as PowerPoint slideHighlights
► Novel hybrid compounds between 2-benzylbenzofuran and imidazole were prepared.
► Their antitumor activity were evaluated.
► The hybrid compounds 47 and 46 were found to be the most potent compounds.
► The structure–activity relationship results of hybrid compounds were summarized.
Journal: European Journal of Medicinal Chemistry - Volume 62, April 2013, Pages 111–121