Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents

A number of linezolid-like oxazolidino-sulfonamides (7a–y and 8a–b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0–6.0 μg/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented.

A series of new oxazolidino-sulfonamides have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. Further these compounds were also evaluated for their antimycobacterial activities.Figure optionsDownload as PowerPoint slideHighlights
► A new series of oxazolidino-sulfonamides have been synthesized.
► These compounds were evaluated for their antimicrobial activity.
► The newly synthesized compounds exhibited significant antimicrobial activity.
► Compounds 7i and 7v exhibited significant inhibitory activity (MIC, 4.0 μg/mL).
► These compounds were also tested for their anti-tubercular activity.