کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394383 1501157 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7)
چکیده انگلیسی

A series of 36 new phenylsulfanylmethyl[1,4]naphthoquinones (7–42) were synthesized by a three-component reaction that involves lawsone, the appropriate aldehyde and thiols with variable substitution patterns. These reactions involve the in situ generation of o-quinone methides (o-QM) via Knoevenagel condensation and 1,4-nucleophilic addition under conventional heating or microwave irradiation. The new naphthoquinones obtained by this methodology were shown to have moderate to good in vitro antimalarial activity against Plasmodium falciparum (3D7).

Figure optionsDownload as PowerPoint slideHighlights
► We synthesized a series of 36 new phenylsulfanylmethyl-[1,4]-naphthoquinones by a three-component reaction.
► These reactions involve the in situ generation of o-quinone methides (o-QM) via Knoevenagel condensation.
► The naphthoquinones prepared shown to have moderate to good in vitro antimalarial activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 59, January 2013, Pages 48–53
نویسندگان
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