Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.

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► Pharmacodynamic hybrids inhibiting COX-2 isoenzyme.
► Improved solubility due the introduction of an ionisable moiety on the side chain.
► An enhanced nitric oxide releasing profile was highlighted by ex-vivo studies.
► In vivo testing highlighted anti-nociceptive properties for this compounds.