Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist

► N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamides were synthesized. ► Synthesized compounds exhibited adipogenesis activity. ► PPARγ agonism of the series translated into in vivo efficacy in db/db mice.