Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.

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► Synthesis of (benzo)isoindole-substituted aglycoristocetin derivatives.
► Antibacterial data showing remarkable efficacy against resistant strains.
► High antiviral activity against influenza A viruses.
► Characterization of the fluorescent properties of new derivatives.
► Demonstration of aggregation properties.