کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394795 1501185 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of flavonoids on the Aβ(25-35)-phospholipid bilayers interaction
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Effect of flavonoids on the Aβ(25-35)-phospholipid bilayers interaction
چکیده انگلیسی

Amyloid-β peptide (Aβ) is the major component of amyloid deposits found in the brain tissue of Alzheimer patients. The tendency of amyloid peptide to form amyloid plaques is known to be related to the features of the plasma membrane.Flavonoids, a group of naturally occurring molecules, exert beneficial properties to human health thanks to their antioxidant property; this property depends on their capacity to interact and permeate the cell membrane lipid bilayer.In the present research we report an Electron Paramagnetic Resonance (EPR) investigation of 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) membranes interacting with the β-amyloid fragment Aβ(25-35), in the presence of flavonoids rutin, quercetin, naringin and naringenin. Our results, evidencing a flavonoid-dependent rigidifying effect of the bilayer, may provide the molecular basis to explain the known neuroprotective effect of flavonoid compounds.

The effect of several flavonoids on the interaction Aβ(25-35)-phospholipid bilayer is studied by means of Electron Paramagnetic Resonance spectroscopy. The results provide a molecular explanation of the known neuroprotective effect of flavonoids. Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 9, September 2010, Pages 3998–4003
نویسندگان
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