کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1394807 | 1501185 | 2010 | 7 صفحه PDF | دانلود رایگان |
A series of 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives were synthesized and tested for their antimicrobial and antiviral activities. Mannich base derivatives were prepared through the reaction of substituted piperazine or piperidine derivatives on chlorokojic acid and formaline. The structures of the synthesized compounds were confirmed by IR, 1H and 13C NMR, ESI-MS, and elemental analysis. According to the activity studies, compounds 2–7 (MIC: 1–2 μg/mL) were found to be highly active against Bacillus subtilis and Staphylococcus aureus, while compounds 3, 5 and 6 showed significant activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Also, compounds 2–7 were more remarkably active against Candida albicans and Candida parapsilosis (MIC: 4–8 μg/mL). Additionally, compound 2 was the most active one against RNA virus PI-3.
Seven novel 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives (compounds 1–7) were synthesized and tested for their antimicrobial and antiviral activities. Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 9, September 2010, Pages 4089–4095