Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.

A series of derivatives based on the N-amino-4-imidazolidinone scaffold (I) was synthesized and shown to inhibit human neutrophil elastase.Figure optionsDownload as PowerPoint slide