کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394981 1501192 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones
چکیده انگلیسی

This work describes the enantioselective synthesis of a new series of terpenic chiral 9-aminotetrahydroacridine analogues. Several chiral ketones were synthesized from natural monoterpenes in an optically active form and subjected to the cyclodehydration reactions with anthranilonitrile in the presence of BF3·Et2O as catalyst. The 9-aminotetrahydroacridine analogues were tested as acetylcholinesterase (AChE) inhibitors. Based on qualitative structure–activity relationship some trends are suggested.

This work describes the enantioselective synthesis and AChE Inhibitory activities of a new series of terpenic chiral 9-aminotetrahydroacridine analogues. Based on qualitative structure–activity relationship some trends are suggested.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 2, February 2010, Pages 526–535
نویسندگان
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