Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents

A series of N-alkylated derivatives of nitroimidazolyl oxazolidinones 6a–i with various substituent at N-1 position of the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 μg/mL against Bacillus cereus MTCC 430.). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929.

A series of nitroimidazole derived oxazolidinones 6a–i with various substituents at the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative resistant bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 μg/mL against Bacillus cereus (MTCC 430). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929.Figure optionsDownload as PowerPoint slide